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KMID : 0366119730010010043
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Korean Journal of Applied Microbiology & Bioengineering
1973 Volume.1 No. 1 p.43 ~ p.50
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Studies on the Synthesis of Mannich Bases of Hexachlorophene and their Antimicrobial Activities
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Abstract
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Thirty-three Mannich bases of 2, 2´-methylene bis (3, 4, 6-trichlorophenoxy-acetic acid)were synthesized hexachlorophene as potential antimicrobial agents and tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Trichophyton rubrum, Microsporum gypseum, Epidermophyton floccosum, Aspergillus niger and Aspergillus oryzae in vitro. It was found that:1) 2, 2´-Methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(N, N-diethylamino) propionic acid] and 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(N, N-dimethynlamo)propionoic acid] were active against Staphylococcus aureus and Bacillus subtilis at the concn. of 1 ㎍/ml respectively; 2) 2, 2´-Methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(m-hydroxy-p-carboxyphenylamino) propionic acid] and 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(cyclohex-ylamino) propionic acid] were active against Trichophyton rubrum at the concn. of 2 ㎍/ml respectively; 3) 2, 2´-Methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(m-hydroxy-p-carboxyphenyl-amino) propionic acid] and 2, 2´-methylene bis [α-(3, 4, 6-trcihlorophenoxy)-β-(piperidino) propionic acid] were active against Microsporum gypseum at the concn. of 2 ㎍/ml respectively; 4) 2, 2´-Methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(m-hydroxyphenylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(m-hydroxy-p-carboxy phenylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(o-chlorophenylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(o-chloro-p-nitrophenylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(methylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(hydroxylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(cyclohexylamino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(morpholino) propionic acid], 2, 2´-methylene bis [α-(3, 4, 6-trichlorophenoxy)-β-(p-sulfophenylamino) propionic acid] and 2, 2´-methylene
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